Dr. Ertan Beyatlı

What is a macrogol? Where is it used?

(Update: ) - Digestive System Diseases

My dating story with Macrogol 4000

A few days ago from abroad (Finland) Umbilical Hernia I had a patient who came for treatment.

After a detailed examination, I suggested surgery to him and performed the surgery the next day.

One day after surgery patient, "Sir I'm fine today, but I just feel like I have a little constipation", said.

I said that generally this situation can be experienced for a few days after surgery due to inactivity.

I also stated that it was caused by the side effects of some medications given before, during and after the surgery.

At the same time, I emphasized that this situation is not permanent, but temporary. I suggested that he drink plenty of water and take a walk.

My patient with a sweet smile, "Sorry my teacher, but I did not tell you, they were actually giving me a medicine for constipation abroad. It is a natural medicine and has no side effects. I took that medicine today and constipation disappeared within 2-3 hours. I wanted to inform you about this situation, teacher.", said.

First of all, this drug is relieving constipation so I thought it was "laxative".

However, my patient continued to explain. Sir, this drug is on the list of the most used drugs in Finland and other European countries and is a completely harmless and natural drug, dedicate.

When I heard that, I was honestly curious. Let me see what is this medicine, I said 🙂

As if waiting for this question, the patient took out the medicine as if putting his hand in the pocket of the jacket run and you're welcome, he said. I picked up the box of the medicine and tried to read the Finnish (Finnish) inscriptions on it. On the box:

"PEGORION 12g ", below that"macrogol. 4000It was writing.

Obviously, this drug and its contents before I did not see, did not hear and in my student years i didn't read. So I recorded his name in my notes and decided to research it later.

Drug-related research I will do yaptım and the results continue to this article. I will add I added 🙂. However, for now, there is a lot of information about this drug. a brief and concise knowledge I can give:

Macrogol 4000 - Long-term persistent in children aged 8 years and older, adults, elderly, pregnant and breastfeeding mothers constipation (Chronic Constipation) used in situations.

Macrogol - An effective osmotic laxative

Constipation is a distressing condition that affects 12% of the global population. This can be caused by many factors - from a fiber diet, to a lack of exercise, and pregnancy. Also, if constipation becomes chronic, it can continue painfully for several months. Also as a result of constipation from the anus hemorrhoids (hemorrhoids) may occur. (see Hemorrhoids Treatment)

Polyethylene glycol (PEG / macrogol 4000)

The history of polyethylene glycols (PEGs) began in 1859 with Laurenco's heating of ethylene glycol and 1,2-dibromoethane and isolated oligo (ethylene glycol) heated by fractional distillation. PEGs are ethylene glycol with a synthetic ether bond made by combining units of joined, unbranched, hydrophilic polymers.

Laxatives are designed to relieve the bothersome symptoms of constipation and can work in a variety of ways, including emollient, contact, clump-forming, and osmotic mechanisms. Given this diversity, different laxatives can also trigger a number of side effects in the human body. A highly effective way to treat constipation that aims to minimize any side effects is an osmotic laxative known as macrogol.

How does macrogol work as a laxative?

What is constipation?

Dry and hard stools can be defined as difficult and infrequent bowel evacuation. Constipation (constipation)

How does constipation occur?

Constipation begins with the slowing of bowel movements and the absorption of the liquid content of the stool in the intestine and the drying of the stool. As a result of drying, the movement of the stool in the intestine becomes more difficult. As a result, the stool becomes dry and solid, sparse and forced defecation, stomach pain such complaints occur.

Macrogol can be prepared as a pleasant-tasting instant drink (= powder for oral solution). Macrogol particles bind to the water molecules in the beverage and carry these water molecules to the column.

In the colon, water molecules trapped by macrogol particles help soften and lubricate stool and slightly increase stool volume. The small increase in stool volume activates colonic peristalsis by moving softened stools towards the intestines.

This initiates the defecation reflex that soothes constipation patients.

Advantages of macrogol

Unlike other osmotic laxatives, macrogol does not lead to habit and offers a number of other benefits. For example, it does not require drawing water into the column from surrounding tissues and therefore prevents dehydration. At the same time, the average stool frequency is higher than other laxatives, the straining required to pass stool is lower.

“Constipation is a condition that needs attention and can cause serious health problems if left untreated. Constipation, which has many reasons such as diseases, medications used for treatment, emotional stress, is one of the common problems. Constipation can be seen in up to 40% of adults. "

Prof. Dr. Levent Erdem

What macrogol can help the patient range is very wide. Safe for pediatric use, special preparations available for children under two years old, pregnant and breastfeeding women can also benefit from short-term treatments. Macrogol is also recommended for patients with cardiovascular disease or kidney failure who cannot take many other osmotic laxatives.

Finally, other laxatives unlike its side effects macrogol:

  • It reduces the risk of stomach pain
  • Can be combined with electrolytes to ensure minimum ion loss
  • Does not affect nutrient absorption
  • Effective throughout the column
  • Doesn't cause bloating
  • Does not cause colon acidification

Offering a variety of pleasant flavors to enhance the patient experience, macrogol is a safe and effective laxative that relieves the uncomfortable symptoms of constipation. There are also unsweetened versions that can be mixed with juice or other liquids.

Indications for use

Macrogol is useful in treating constipation in adults and children.

Description of the product

Macrogol 4000 or 3350 naturally regulates the intestines; It is indicated in cases of chronic constipation and occasional irregularities.
Macrogol 3350 is a blend of high molecular weight polymers that are not absorbed and metabolized by the gut microbiota. Macrogol 3350 acts as a pure osmotic agent that keeps water at the intestinal level; This promotes intestinal peristalsis or softening of stools and ultimately evacuation without causing cramping, abdominal pain or emergency conditions.

  • not absorbed in the intestine
  • It is excreted in the stool in an unchanged form
  • does not ferment
  • Does not irritate the mucosa
  • Efficiency does not decrease over time
  • It can be taken by children over 3 years old.


Unless otherwise stated, the recommended Macrogol 4000 or 3350 dosage

  • Adults, the elderly and children over 12 years old: 1 whole sachet (13.3 g) 1-3 times a day dilute the contents in 125 ml of water (1 glass of still water)
  • Children 7-11 years old: Half a sachet (6.65 g) twice a day, diluting the contents in 62.5 ml of water (half a glass of still water)
  • Children 3-6 years old: half sachet (6.65 g) once a day diluted in 62.5 ml of water (half a glass of still water)
  • Do not give to children under 3 years old.
  • It does not contain gluten and lactose.

It is possible to find this product under many different names in pharmacies: Normalene® Macrogol 3350, polyethylene glycol 3350, PEG, PEGORION 12g, Movicol, DulcoSoft, SoftLax, MiraLAX, ClearLAX, Osmolax, GlycoLax.




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