Dr. Ertan Beyatlı

Can autophagy science improve your health?

(Update: ) - general subjects

In this article I will mention a little known scientific fact; New and natural way to lose weight, look younger and prolong life ..

Autophagy is a natural regeneration process that occurs at the cellular level in the body and reduces the likelihood of some diseases and prolongs life.

Autophagy name 1963 It was proposed by the Belgian biochemist Christian de Duve. 1990The identification of genes related to autophagy in yeast in the XNUMXs allows researchers to determine the mechanisms of autophagy. 2016 Japanese scientist Yoshinori Ohsumiwon the Nobel Prize for his discoveries in autophagy mechanisms. These have led to a better understanding of diseases such as Parkinson's and dementia.

Since then, pharmaceutical companies and academics have been competing to find drugs to stimulate the process, and diet and health experts have entered the race, claiming that fasting is a natural stimulation of the process by exercising at high intensity and restricting carbohydrates.

So what do scientists say?

“Certainly, evidence from experiments in mice suggests this will happen,” said Dr David Rubinsztein, professor of molecular neurogenetics at the University of Cambridge and the UK Dementia Research Institute.

"There are studies where they initiate the process using genetic tools or drugs or fasting, and in these situations animals tend to live longer and be in better shape overall."

However, he said it is not yet clear how this translates to people.

“For example, in mice, you see the effects of fasting within 24 hours of the brain and in parts of the body, such as the liver, much faster. "But even though we know that fasting is good, we still don't know exactly how long people need to fast to see the benefits," he said.

That said, fasting promotes autophagy, and its benefits have also been proven by other studies, he said.

What is autophagy?

Autophagy, “self-eatingAnd means "hollow". It consists of two words as auto and Faji. It is a word of ancient Greek origin (aὐτόφαγος autóphagos).

  • Of cells spoiled its components and it is the natural process it recycles.
  • Fuel for energy and cell regeneration Provides building blocks for
  • After infection, autophagy Can destroy bacteria and viruses
  • Cells, of aging It uses autophagy to get rid of damaged proteins and organelles to counteract their negative effects on the body.

OTOFAJI ensures the regular breakdown and recycling of cellular components. Targeted cytoplasmic elements in macroautofission are isolated from the rest of the cell within a double-membrane vesicle known as the autophagosome. The autophagosome eventually fuses with lysosomes and the contents degrade and recycle.

What is autophagy?

While OTOFAJI in the disease is seen as an adaptive response to stress, it appears to increase cell death and morbidity in other conditions, while providing survival. In the starvation state, the breakdown of cellular components maintains cellular energy levels, allowing the cell to survive.

Types of Autophagy

There are four pathways of auto-phage, and these are mediated by the autophagy-linked genes and the enzymes associated with them:

  • Macro-auto-phage
  • Micro-auto-phage
  • CMA-auto faji, chaperone mediated
  • Mito-faji