Dr. Ertan Beyatlı

Is it possible to lose weight with Stomach Botox?

(Update: ) - Digestive System Diseases

Stomach Botox is applied to an area close to the exit hole of the stomach in obese patients. botulinum toxin substance is the process of injecting. This procedure is done with upper digestive system endoscopy.

General Information

Toxin substance to the antrum and prepyloric part of the stomach during the endoxopia procedure (botox, botox) is injected. Thus, the muscles at the exit of the stomach are paralyzed (gastroparesis) food and drinks stay in the stomach longer and create a feeling of satiety. Normally, the stomach's emptying time is 4-6 hours.

Obesity is now a worldwide health problem. Since metabolic diseases, diabetes, hypertension, cardiovascular and hepatobiliary diseases are common in obese individuals, it increases the risk of morbidity and mortality. Unfortunately, various diets, pharmacological drugs and behavioral treatments used for weight loss have partial results and are short-term. (one)

Surgical interventions (tube stomach, gastric folding, gastric banding, and bypass), although they may be effective in some patients, they are invasive and can have serious complications.

What is botulinum toxin (Botox)?

Botulinum toxin A

It is a strong, long-lasting inhibitor of muscle contraction in both striated and smooth muscles. Gram (+) anaerobic bacteria "Clostridium botulinumProduced by ”. This substance prevents the secretion of enzymes (acetylcholine) from the nerve endings, causing a paralysis of the muscles, "botulism".

Botox (Botulinum) is also used in the treatment of many diseases and since it does not directly penetrate the brain and nervous system, it has not been observed that it directly affects the central nervous system. The therapeutic effects of botulinum toxin were demonstrated in the 1970s.

Cervical dystonia, blepharospasm, limb spasticity, headache prophylaxis, chronic anal fissureMore than 50 therapeutic uses are reported in the literature, including hyperhidrosis, essential tremor and achalasia.

Elsevier M. consulte

Although complications may develop when injected by inexperienced people, the use of botox for aesthetic purposes seems to be a safe application. Although undesirable effects and some sequelae are temporary, more serious complications may occur after botox injection in some patients with deep wrinkles, plastic surgery on the face, and previous neuromuscular disease. Botox mediated facial rejuvenation By being more conservative in all procedures, it is possible to reduce complications by using appropriate botox doses and appropriate injection techniques. (2)

In clinical studies, they assumed that stomach Botox, which relaxes the muscles, would help people lose weight because the stomach would slow the emptying rate on its own. But in the new study, the researchers tested a different theory: whether Botox can block the vagus nerve, which connects the brain and stomach and controls feelings of hunger and satiety. (3)

However, in a study published by the American Gastroenterological Association, some different determinations were made (4). These studies suggested that gastric injections of Botulinum toxin A (BTA) may delay gastric emptying, but do not cause obese individuals to feel fuller, change their eating behavior, or lose weight, according to the journal Clinical Gastroenterology and Hepatology in February.

Study participants received 1 injection of BTA (100, 300, or 500 U) or placebo in the gastric antral muscularis propy, each guided by endoscopic ultrasound. Gastric emptying of solid foods was measured by scintigraphy. Participants' body weights were also measured every 2 weeks, while satiety (based on the maximum tolerated volume in a caloric drink test), calorie intake (based on a questionnaire), gastrointestinal symptoms, and psychological aspects of the meal were also measured.

BTA Gastric effect
BTA Gastric effect

Thus, although the stomach injection of BTA slows gastric emptying, it does not increase the feeling of satiety or cause a loss of body weight. The authors noted that higher doses of BTA than those tested were unlikely to cause additional delays in gastric emptying or weight loss. (5)

How is Stomach Botox made?

Injection into the gastric mucosa
Injection into the gastric mucosa

Botox, the same treatment used in the treatment of wrinkles, is also effective in the treatment of gastroparesis. It is a less invasive procedure that works on the same principle as a pyloroplasty. Botox is given locally, so side effects are not common.

Before the procedure:

Made in sleep Endoscopy process stages are applied. The patient is instructed to come to the hospital approximately 30-60 minutes before the procedure. Preparations such as heart monitor, IV vascular access, oxygen and sedation are made.

During the process:

While the patient is sedated, the doctor examines the esophagus, stomach, and pyloric sphincter. Botox is injected to relax the pyloric sphincter muscles. The stomach botox process takes about 15-30 minutes.

Stomach Botox Benefits and Advantages

  • To be easy
  • Low cost
  • Application in a short time, daily
  • Less invasive and risky than surgery
  • Fast effect on patients on diet

Stomach Botox Harms and Disadvantages

  • It can be done by inexperienced people as it is easy, cheap and short procedure.
  • Bleeding
  • Perforation, perforation of the stomach
  • Necrosis of the stomach lining and stomach ulcers
  • It is not permanent. The effect of stomach botox continues for 6-12 months. It needs to be applied again.
  • Doesn't give the same result when repeated


  1. https://www.em-consulte.com/en/article/156118
  2. http://www.turkiyeklinikleri.com/article/tr-botulinum-toksini-farmakolojisi-ve-terapotik-perspektif-48668.html
  3. https://www.livescience.com/54892-botox-weight-loss.html
  4. http://journalsblog.gastro.org/stomach-botox-for-weight-loss/
  5. https://agajournals.wordpress.com/
  6. https://www.g-pact.org/gastroparesis/treatment-options/surgical-intervention
Tags: , , .