Dr. Ertan Beyatlı

Is there a definitive solution for FMF Disease?

(Update: ) - general subjects

The common name of the disease in the society is "FMF", in other words Familial Mediterranean Fever. Familial Mediterranean Fever.

Causes | Symptoms | Treatment | Colchicine

What is FMF?

Familial Mediterranean Fever (AAA) is a disease that progresses in attacks. Complaints of abdominal pain and fever are seen in attacks.

As the name of the disease suggests family that is, it is an inherited disease (autosomal recessive Pyrin gene).

FMF especially Coast to the mediterranean is common in countries where there is. It is common among Turkish, Arab, Jewish and Armenian races.

FMF can often be confused with other acute abdominal diseases, such as acute appendicitis.

Causes of FMF

Clinical findings occur as a result of a mutation in the gene called pyrin.

It is inherited genetically.

Coexistence of two diseased genes causes illness, while carrying one disease gene does not cause illness. Those people "carrierIt is called ".

FMF Symptoms

FMF attacks

It is characterized by the recurrence of the following symptoms and the duration of 3-4 days:

  • Fire
  • Abdominal pain (peritonitis due to peritoneal inflammation)
  • Chest pain (pleuritis due to pleurisy)
  • Joint pain (arthritis due to joint inflammation)
  • Dermatitis. Sometimes, skin rash on the front of the legs can also be added to the picture.

Generally, these complaints can disappear spontaneously within 3-4 days, even if no treatment is given.

Repetitive attacks in our body over time amyloid It causes the buildup of a protein called.

Amyloid accumulates most often in the kidneys, to chronic kidney failure why could it be. To a lesser extent, it may accumulate in the vessel walls and cause vasculitis.

FMF symptoms


Diagnosis is made based on the following data:

  • clinical findings
  • family history
  • examination
  • laboratory tests. None of these tests are specific to FMF and are used to support the diagnosis of the disease during attacks. These tests are briefly as follows:
    • leukocyte height
    • sedimentation increase
    • CRP height
    • fibrinogen height

The benefit of genetic examination in patients is limited because the mutations identified so far have been found positive in only 80% of Familial Mediterranean Fever patients.

However, genetic analysis can be helpful in atypical cases.

FMF Treatment

In Familial Mediterranean Fever colchicine treatmentIt has been determined that the majority of patients prevented attacks and the development of amyloidosis.

In patients who do not comply with treatment or who are late in starting colchicine amyloidosis it is still a serious problem.

Colchicine treatment forever should last.

The treatment of colchicine is known to be a safe, appropriate and vital treatment for patients with familial Mediterranean fever.

It is recommended to use even if the patient becomes pregnant. Colchicine has not been shown to have a harmful effect on the baby.

Nevertheless, it is recommended to examine the genetic structure of the fetus by performing amniocentesis to pregnant familial Mediterranean fever patients.

What is colchicine?

Colchicine is a medicine derived from the onion and seed of the wort (Colchicum autumnale) plant.

It can be used in the following situations:

  • Familial Mediterranean Fever (FMF)
  • Gout
  • Behcet 's disease

Side effects: nausea, vomiting, cramps, stomach pain, diarrheahair loss, impaired sperm production, anorexia (loss of appetite)

Conditions where colchicine should not be used

  • Severe liver disease
  • severe digestive system disease (Spastic column IBSStomach ulcer)
  • serious heart disease
  • malignant blood disease
  • those undergoing hemodialysis treatment
  • those with severe kidney disease (creatinine clearance <10mL / min)
  • pregnant women, lactating women
  • It should not be used with some drugs. For example: pain relievers, cancer drugs, alcohol, Cyclosporine, clarithromycin, erythromycin, Tolbutamide.
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